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Conducting weird scientific experiments, crazed Dr. James Brewster,(Bela Lugosi), aided by his colleague Dr. Randall, has managed to transform himself into a hairy, stooped-over ape-man. Desperately seeking a cure, Brewster believes only an injection of recently-drawn human spinal fluid will prove effective. With Randall refusing to help him, it falls to Brewster and his captive gorilla to find appropriate donors. When his demand for spinal fluid exceeds his supply, Brewster and his primate stalk the streets in a frenzied killing spree to acquire more of the mercurial juice.